Lighting Up the Dark Genome

Decoding the hidden mechanisms of the dark genome containing endogenous retroelements to innovate precision cancer treatments and transform oncology

Lab Research Pillars

Uncovering the role of the Dark Genome in cancer initiation and driving cancer progression

Unlocking silent DNA sequences to understand how cancers start and spread through the body

Tapping into extracellular vesicles as carriers of endogenous retroelements for cancer detection

Using molecular fingerprints of endogenous retroelements in extracellular vesicles in the blood to detect cancer early and create personalized treatments

Exploiting endogenous retroelements as novel targets for immunotherapy and targeted drug therapy

Identifying novel retroelement proteins and signaling mechanisms for therapeutic targeting

Our Scientific Team

Dr. Laszlo Radványi

Dr. Zhenbo Zhang

Dr. Priyoshi Lahiri

Dr. Arsala Ali

Aimee Garcia Castro

Principal Investigator & Canada Research Chair

Senior Scientist – ERE Biology & EV Diagnostics

Postdoctoral Fellow – Cancer Immunology & HERV Antigens

Bioinformatics Scientist – Dark Genome & Retroelements

MSc Student – Biochemistry, Microbiology & Immunology

Recent Breakthroughs

Our latest research has identified specific dark genome markers that drive oncogenic transformation. By mapping these silent genetic elements, we are paving the way for precision oncology and innovative therapeutic strategies that target the root of cancer development.

Research Platforms

We utilize cutting-edge molecular techniques and computational frameworks to illuminate the dark genome, identifying novel markers for precision cancer diagnostics and intervention.

Explore the Different Technologies Used in Our Lab

DECODING NON-CODING REGIONS • PRECISION ONCOLOGY • THE DARK GENOME •